RecruitingNCT03546387

Determining Whether Multiple Anesthesia Exposures Affect Cognitive Function for Retinoblastoma Patients

Incidence of Neurocognitive Deficits in Patients After Treatment for Retinoblastoma With Multiple Anesthesia Exposures

Sponsor

Memorial Sloan Kettering Cancer Center

Enrollment

75 participants

Start Date

May 7, 2018

Study Type

OBSERVATIONAL

Conditions

Retinoblastoma Pediatric Retinoblastoma

Summary

The purpose of this study is to see if there is a difference between the development of the brain (neurodevelopment) in children who have been treated for retinoblastoma with multiple anesthetic exposures, compared with brain development in children who have never had anesthesia.

Eligibility

Min Age: 6 YearsMax Age: 17 Years

Inclusion Criteria1

Age ≥ 6 and < 17 years old

Exclusion Criteria9

Diagnosis of any secondary disease associated with developmental delay
History of second cancer diagnosis
Legal Blindness
Past surgery of any type, with the exception of enucleation for retinoblastoma
Past exposure to anesthesia for surgical intervention
More than one anesthesia encounter for surgical intervention before diagnosis at MSK
Past External Beam Radiation for treatment of retinoblastoma
Past systemic chemotherapy
Non-native speaker of English; however, children whose parents speak only Spanish will be included, because the tests for parents are available in Spanish

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Interventions

OTHERWechsler Intelligence Scale for Children, Fifth Edition (WISC-V)

the WISC-V assessment produces a Full Scale IQ (FSIQ) used for primary power consideration in this study. The FSIQ is the most comprehensive global ability score on the WISC-V, and it has been conventionally reported and interpreted as an estimation of overall intellectual ability

OTHERCalifornia Verbal Learning Test, Children's Version

Used to assess verbal learning and memory in children and adolescents

OTHERBeery Developmental Test of Visual Motor Integration, 6th edition

Helps assess visual-motor skills in children and adults.

OTHERGrooved Pegboard Test

Measures dexterity

OTHERBehavior Assessment System for Children/Parent Report

The Behavior Assessment System for Children/Parent Report is a questionnaire that assesses the social-emotional and behavioral functioning (e.g., anxiety, depression, attention, hyperactivity, adaptability, leadership, social skills, etc.) in children between the ages of 2 and 22 years, and is available in English and Spanish.