RecruitingNCT03551951

Tumor Cell and DNA Detection in the Blood, Urine, and Bone Marrow

Tumor Cell and DNA Detection in the Blood, Urine and Bone Marrow of Patients With Solid Cancers and Subjects Undergoing Lung Cancer Screening

Sponsor

University of Missouri-Columbia

Enrollment

320 participants

Start Date

Jul 1, 2016

Study Type

OBSERVATIONAL

Conditions

Colorectal, Cancer Esophageal Cancer Pancreatic Cancer Gastric Cancer Non-small Cell Lung Cancer Hepatocellular Cancer

Summary

Patients with resectable solid primary cancers and even limited number of metastases are potentially curable. However, most patients develop recurrences despite surgery. Also, early detection of lung cancer with low dose CT screening may cure patients at an early stage. Circulating and disseminated tumor cell (CTC/DTC) and circulating cell-free (cf) DNA isolation from the blood, urine and bone marrow will increase understanding of cancer spread and advance knowledge to develop individualized therapies and improve screening.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study looks at whether cancer cells and cancer DNA can be detected in blood, urine, and bone marrow samples — essentially testing whether simple body fluid tests might one day help detect or monitor solid cancers like lung, stomach, colon, and others. **You may be eligible if...** - You are older than 18 years - You have been diagnosed with a solid cancer (such as lung, esophageal, stomach, bile duct/pancreas, colorectal, melanoma, or sarcoma) at any stage, OR - You are having surgery for a non-cancer reason and have no current or past history of cancer (you would serve as a healthy comparison) - Participants of all genders and ethnicities are welcome **You may NOT be eligible if...** - You do not fall into one of the defined groups above - You are not scheduled for surgery Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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