RecruitingNCT03566797

Secondary Sclerosis Cholangitis Prospective

Secondary Sclerosing Cholangitis in Critically Ill Patients (SC-CIP): A Prospective Cohort Study


Sponsor

Medical University of Graz

Enrollment

380 participants

Start Date

Jul 20, 2018

Study Type

OBSERVATIONAL

Conditions

Summary

SC-CIP is increasing in patients after critical illness. Pathogenesis is still largely unclear. Gut microbiome composition, gut permeability, bacterial translocation, inflammation and/or genetic variants contribute to the pathogenesis The aim of this project is to study gut microbiome composition, gut permeability, bacterial translocation, inflammation, bile acid composition and genetic polymorphisms by conducting a prospective cohort study in patients with a high risk to develop SC-CIP.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tracks patients with a rare liver and bile duct condition called secondary sclerosing cholangitis — where the bile ducts progressively scar and narrow, usually following a severe illness or injury — to better understand how it develops and progresses over time. **You may be eligible if...** - You are willing and able to give informed consent to participate in the study, or a designated representative (as permitted by the review board) can consent on your behalf - You are older than 18 years of age **You may NOT be eligible if...** - You are unwilling to provide consent - You are 18 years old or younger Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Medical University Graz

Graz, Austria

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NCT03566797