RecruitingNCT03568266
Pharmacogenomics of Asparaginase Induced Hepatotoxicity
Pharmacogenomics of Age-Specific, Asparaginase-Induced Hepatotoxicity in Patients With Acute Lymphoblastic Leukemia
Sponsor
University of Southern California
Enrollment
500 participants
Start Date
May 22, 2018
Study Type
OBSERVATIONAL
Conditions
Summary
This pilot trial studies the impact of genetic information on developing liver damage caused by asparaginase in participants with newly diagnosed acute lymphoblastic leukemia. Testing saliva samples may help doctors find certain genetic markers that may predict whether participants will tolerate asparaginase, which is given as part of clinical care for acute lymphoblastic leukemia.
Eligibility
Min Age: 18 Years
Inclusion Criteria4
- Newly diagnosed with acute lymphoblastic leukemia (ALL) - no prior treatment for ALL
- Receiving asparaginase as part of the primary treatment regimen
- Ability to understand and the willingness to sign a written informed consent
- For retrospective recruitment, those who have received asparaginase between 2012 and 2017; and are current patients of University of Southern California (USC)
Exclusion Criteria1
- Patients who are unable to give informed consent
Interventions
PROCEDUREBiospecimen Collection
Undergo collection of saliva
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT03568266
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