Modeling and Closed-loop Control of Depth of Anaesthesia

Maintaining the correct depth of anesthesia during surgery is critical — too light and the patient may be aware; too deep and recovery is prolonged with increased side effects. This study develops and tests mathematical models and automated control systems that can monitor depth of anesthesia in real time and adjust drug delivery accordingly, without constant manual input from the anesthesiologist. This is done by analyzing brain activity signals (like EEG), heart rate patterns, and other physiological data. The goal is to create a closed-loop system — similar to cruise control in a car — that keeps anesthesia at exactly the right level throughout an operation. Such systems could improve safety, reduce drug use, and free anesthesiologists to focus on other critical aspects of patient care. You may be eligible if: - You are between 20 and 70 years old - You are undergoing vitreoretinal eye surgery or brain surgery under general anesthesia, or need sedation in an ICU - Your overall health status is ASA class 1–3 You may NOT be eligible if: - Your health status is very poor (ASA class 4 or higher) - Your BMI is above 35 - You use illicit drugs or take regular opioid painkillers - You take psychotropic medications - You have severe psychiatric illness or a central nervous system disease - You have atrial fibrillation or another arrhythmia affecting monitoring - You have taken benzodiazepines recently Talk to your doctor to see if this trial is right for you.