RecruitingNCT03569839

Modeling and Closed-loop Control of Depth of Anaesthesia

Sponsor

University of Ljubljana

Enrollment

50 participants

Start Date

Sep 14, 2017

Study Type

OBSERVATIONAL

Conditions

The Focus is to Develop a Closed-loop Control System for Anaesthesia in Vitroretinal Surgery, Surgery Due to Expansive Processes in Head, and Long-term Sedation

Summary

The study evaluates the effect of anaesthetic agents to depth of anaesthesia. An improved PK-PD model wil be developed that will provide the basis for understanding the mechanisms, simulating various scenarios and developing algorithms for better and safer administration of anaesthetic agents.

Eligibility

Min Age: 20 YearsMax Age: 70 Years

Inclusion Criteria4

patients having vitroretinal surgery in general anaesthesia
patients having brain surgery in general anaesthesia
patients needing sedation in ICU
ASA 1-3

Exclusion Criteria9

ASA \> 3
BMI \> 35
drug addicts
patients taking psychotropic medicines
patients taking opioid analgesics (including tramadol)
severe psychiatric disease
central nervous system disease (except the reason for surgery)
arrhythmia affecting or preventing the measurements (e.g. chronic atrial fibrillation)
patients that received benzodiazepines

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Interventions

DRUGPropofol

Patients undergoing surgery, TIVA (total intravenous anaesthesia)

Locations(1)

University Medical Centre Ljubljana

Ljubljana, Ljubljana, Slovenia

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NCT03569839