RecruitingPhase 1Phase 2NCT03582124

Panitumumab-IRDye800 in Detecting Cancer in Participants With Lung Cancer During Surgery

A Phase I/II Study Evaluating the Safety and Pharmacokinetics of Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Lung Cancer During Surgical Procedures


Sponsor

Stanford University

Enrollment

30 participants

Start Date

Jul 19, 2018

Study Type

INTERVENTIONAL

Conditions

Summary

This phase I/II trial studies the best dose and timing of panitumumab-IRDye800 in detecting cancer in participants with lung cancer during the surgery. Panitumumab-IRDye800 is a combination of the antibody drug panitumumab and IRDye800CW, an investigational dye that can be seen using a special camera. Panitumumab-IRDye800 may attach to tumor cells and make them more visible during surgery in patients with lung cancer.


Eligibility

Min Age: 19 Years

Plain Language Summary

Simplified for easier understanding

This study tests a new imaging technique that uses a specially labeled antibody (panitumumab-IRDye800) injected before surgery to help surgeons see and identify cancer tissue in real-time during lung surgery, potentially improving how completely cancer can be removed. **You may be eligible if...** - You have a suspicious lung nodule or mass that may be cancer (primary lung cancer or a lung metastasis), with or without a prior biopsy - You are scheduled for standard surgery to remove the lung nodule or mass - You are in adequate physical condition (Karnofsky score at least 70%, or ECOG level 0–2) - Your blood counts (hemoglobin, white blood cells, platelets) meet the required minimums - Your kidney function is within acceptable range **You may NOT be eligible if...** - You are not scheduled for lung surgery - Your blood counts or kidney function are too low to meet the eligibility requirements Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURENear-Infrared Fluorescence Imaging

Undergo imaging

DRUGPanitumumab-IRDye800

Given IV

OTHERPharmacokinetic Study

Correlative studies

PROCEDURETherapeutic Conventional Surgery

Undergo surgery


Locations(1)

Stanford University, School of Medicine

Palo Alto, California, United States

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NCT03582124


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