RecruitingNot ApplicableNCT03600779

Application of ihMT MRI in Multiple Sclerosis

Application of the Inhomogeneous Magnetisation Transfer MRI (ihMT) Technique, a New Myelin-specific MRI Technique, in Multiple Sclerosis

Sponsor

Assistance Publique Hopitaux De Marseille

Enrollment

85 participants

Start Date

Jun 14, 2018

Study Type

INTERVENTIONAL

Conditions

Sclerosis, Multiple

Summary

The development of in vivo biomarkers sensitive to myelin disruption represents a major clinical need to be able to monitor the demyelination processes as well as the effect of remyelinating therapies in multiple sclerosis. The investigators recently proposed a technique, derived from the conventional magnetisation transfer (MT): inhomogeneous Magnetisation Transfer (ihMT). In preliminary studies, this simple-to-implement and robust technique has shown great sensitivity for evaluating the demyelination processes. The goal of the project is to evaluate the ability of ihMT to measure and describe the spontaneous demyelination and remyelination processes involved in active lesions in a population of patients with MS at the the disease onset.

Eligibility

Min Age: 18 YearsMax Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This study is using a new type of MRI brain scan technique (called inhomogeneous magnetization transfer, or ihMT) to better understand damage to the protective coating around nerve fibers in people with multiple sclerosis (MS), and comparing results to healthy volunteers. **You may be eligible if...** - You are between 18 and 45 years old - You are covered by health insurance - For MS patients: you have the relapsing-remitting form of MS (diagnosed by McDonald 2010 criteria), your disease was diagnosed within the last 5 years, and your latest brain MRI shows at least one active lesion **You may NOT be eligible if...** - You have a progressive form of MS (such as primary or secondary progressive MS) - You have a metal implant or other condition that prevents you from having an MRI - You are pregnant - You are under 18 or over 45 years old Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEinhomogeneous Magnetisation Transfer (ihMT) sequence

robust technique has shown great sensitivity for evaluating the demyelination processes using MRI at 1.5T

DEVICEinhomogeneous Magnetisation Transfer (ihMT) sequence at 3T

robust technique has shown great sensitivity for evaluating the demyelination processes using MRI at 3T

Locations(1)

Assistance Publique Des Hotipaux de Marseille

Marseille, PACA, France

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NCT03600779

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