Fecal Microbiota Transplantation for Irritable Bowel Syndrome
Efficacy and Safety of Fecal Microbiota Transplantation for Irritable Bowel Syndrome
Guangzhou First People's Hospital
120 participants
Aug 10, 2018
INTERVENTIONAL
Conditions
Summary
Fecal microbiota transplantation (FMT) is a strategy that infuses a fecal suspension containing a healthy donor's microbiota into a patient's gut to restore his/her intestinal microbiome. FMT has a higher cure rate than standard antibiotic treatment for recurrent Clostridium difficile infections,and shows promising results in Inflammatory bowel disease（IBD）.However, few studies have evaluated whether FMT is effective to treat Irritable bowel syndrome(IBS).The investigators propose to determine the efficiency and safety of FMT in patients with Irritable bowel syndrome.
Eligibility
Inclusion Criteria4
- To be considered eligible for enrolment into the study, subjects must:
- Be able to give written informed consent.
- Males and females aged >18 and <75
- Have IBS as defined by the Rome IV criteria
Exclusion Criteria5
- Subjects will be excluded from the study if they meet any of the below criteria:
- pregnant or having a follow-up of less than 6 months;
- unable to give informed consent;
- suffering from other severe disease ,including liver and kidney failure, cancers, intestinal diseases, inflammatory bowel disease, C difficile infection;
- unable to undergo endoscopy.
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Interventions
200 mL of prepared fecal microbiota suspension from heathy donors' fresh feces was injected into the colon
Infusion of sham
Drugs such as probiotics, antibiotics, antidepressants
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT03613545