RecruitingPhase 4NCT03615742

Diesel Exhaust Induces Glucocorticoid Resistance

Sponsor

University of British Columbia

Enrollment

30 participants

Start Date

Dec 1, 2018

Study Type

INTERVENTIONAL

Conditions

Exposure to Pollution Glucocorticoid Resistance

Summary

The investigators are studying the effects of exposure to diesel exhaust on lung inflammation in the presence and absence of an inhaled corticosteroid. Although data is mixed, studies show that asthmatics have increased lung inflammation and worse symptoms during periods of higher air pollution despite taking their anti-inflammatory corticosteroid medication. One possible reason is that air pollution exposure may decrease the ability of corticosteroids to combat inflammation. To test this volunteers will inhale either a placebo or a corticosteroid, before sitting in an exposure booth for 2 hours breathing either filtered air or diluted diesel exhaust. Samples will be collected before and after exposure to analyze the effects of budesonide and diesel exhaust exposure.

Eligibility

Min Age: 19 YearsMax Age: 49 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at whether breathing diesel exhaust makes asthma harder to treat by making the body resistant to steroid medications (called corticosteroids) that are commonly used to control asthma symptoms. **You may be eligible if...** - You are between 19 and 49 years old - You have been diagnosed with asthma by a doctor, confirmed by breathing tests - Your asthma reacts to a test substance (methacholine challenge PC20 less than 16 mg/mL) **You may NOT be eligible if...** - You are a smoker (including vaping) or have significant smoking history - You regularly take antihistamines, NSAIDs (like ibuprofen), steroids, or other asthma controller medications - You are pregnant or breastfeeding - You have a BMI over 35 - You have a heart condition or irregular heartbeat - You are currently in another study that might interfere Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERPlacebo

Inhalation of air through a Turbuhaler that contains no medication, as a control.

DRUGBudesonide

1.6mg of budesonide from a Turbuhaler.

OTHERFiltered Air

Exposure to HEPA filtered air, as a control.

OTHERDiesel Exhaust

Diesel exhaust standardized to 300µg/m³ of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).

Locations(1)

University of British Columbia

Vancouver, British Columbia, Canada

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NCT03615742