RecruitingNCT03624712

Analysis and Optimization of Predictive and Therapeutic Models in Uterine Neoplasms

Prospective, Tricentric Open Trial on the Analysis and Optimization of Predictive and Therapeutic Models in Uterine Neoplasms

Sponsor

University Hospital Tuebingen

Enrollment

580 participants

Start Date

Jan 1, 2012

Study Type

OBSERVATIONAL

Conditions

Uterine Neoplasms

Summary

Evaluation of clinical, therapeutic and prognostic relevance of new experimental results as well as optimization of therapeutic models and development of a new algorithm for therapeutic plan and therapy in patients with uterine neoplasm

Eligibility

Sex: FEMALEMin Age: 18 Years

Inclusion Criteria5

Confirmed uterine malignancy ( cervical cancer, endometrial cancer, sarcoma)
If operable: surgical primary therapy: laparoscopic/robot-assisted or open radical gyneco-oncological surgery
Written consent
Willingness and ability to participate in all study-specific procedures
Age ≥ 18 years

Exclusion Criteria3

Severe and acute general disease in the last 4 weeks
Acute or chronic psychiatric disorders
Other factors questioning study participation (e.g. acute psychosocial stress, insufficient understanding of nature and consequences of the study, inadequate skills of the German language)

Interventions

DIAGNOSTIC_TESTuterine neoplasms

Analysis of circulating (CTC) and disseminating tumor cells (DTC), determination of Human Papilloma Virus (HPV), Douglas cytology, DNA analysis in blood, proteome analysis, sentinel lymph node detection