RecruitingNot ApplicableNCT03650595

MRI Guided Focal Laser Ablation of Prostate Cancer


Sponsor

University Health Network, Toronto

Enrollment

102 participants

Start Date

Mar 29, 2018

Study Type

INTERVENTIONAL

Conditions

Summary

This clinical research study is designed to determine the ability of in bore MRI guided Focal Laser Ablation (MRgFLA) in patients with early stage carcinoma of prostate. The results will be evaluated by repeated MRI and prostate biopsy. Previous prospective development study demonstrated that FLA may be a viable option for men with low-intermediate risk prostate cancer. The vast majority of patients undergoing this treatment experienced minimal side effects with no peri-operative complications. Over 80% of patients treated with MRgFLA remain on AS and were able to avoid radical therapy at mean follow up duration of 3 years.


Eligibility

Sex: MALEMin Age: 40 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing a minimally invasive procedure that uses laser energy guided by MRI to precisely destroy small areas of prostate cancer, as an alternative to full surgery or radiation, for men with low-to-intermediate risk prostate cancer. **You may be eligible if...** - You are a man between 40 and 80 years old - You have been diagnosed with low-to-intermediate risk prostate cancer (Gleason score 6 or 7 with primary grade 4 or less) - Your cancer is early stage (T1c or T2) and appears to be in only one side of the prostate - Your cancer location has been mapped or identified on MRI **You may NOT be eligible if...** - Your cancer has spread outside the prostate or to lymph nodes - You have a high Gleason score (8 or higher) indicating more aggressive cancer - You have had previous prostate surgery or radiation - You have certain conditions that make MRI unsafe (e.g., certain metal implants) - You are unable to undergo general anesthesia Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEThe TRANBERGCLS|Thermal Therapy

MRI Guided Focal Laser Ablation of Prostate Cancer by The Diode Laser System - The TRANBERGCLS\|Thermal Therapy


Locations(1)

Sangeet Ghai, MD

Toronto, Ontario, Canada

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NCT03650595


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