Phase I Nab-Paclitaxel Plus Gemcitabine With Proton Therapy for Locally Advanced Pancreatic Cancer (LAPC)

This trial is studying whether combining two chemotherapy drugs (nab-paclitaxel and gemcitabine) with proton radiation therapy is safe and effective for patients with pancreatic cancer that cannot be surgically removed but has not yet spread to distant organs. **You may be eligible if...** - You have been diagnosed with pancreatic cancer (adenocarcinoma) confirmed by biopsy or fluid test - Your cancer has not spread to distant organs (non-metastatic) - Imaging shows the cancer cannot be surgically removed at this time - You are in good overall health - You are 18 years old or older **You may NOT be eligible if...** - Your cancer has already spread to distant organs, lymph nodes outside the region, the lining of the abdomen, or caused fluid buildup in the belly - You have had prior radiation to the stomach area - You have serious heart or liver problems - You are pregnant or breastfeeding - You have had prior chemotherapy for this cancer (in some study phases) Talk to your doctor to see if this trial is right for you.