RecruitingEarly Phase 1NCT03665675

Donor Virus-Specific CMV or AdV CTL to Treat CMV or AdV Reactivation or Disease After Solid Organ or HCT

Pilot Study of Haploidentical or Matched Donor Virus-Specific T-cells (Cytomegalovirus (CMV) or Adenovirus (AdV)) to Treat CMV or AdV Reactivation or Disease in Patients After Solid Organ or Hematopoietic Stem Cell Transplantation (HCT)


Sponsor

Sumithira Vasu

Enrollment

20 participants

Start Date

Nov 7, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

This trial studies the side effects and how well allogeneic cytomegalovirus-specific cytotoxic T lymphocytes (donor cytomegalovirus \[CMV\] specific cytotoxic T-lymphocytes \[CTLs\]) or allogeneic adenovirus-specific cytotoxic T lymphocytes (donor adenovirus-specific \[AdV\] specific CTLs) work in treating CMV or AdV reactivation or infection in participants who have undergone stem cell transplant or solid organ transplant. White blood cells from donors may be able to kill cancer cells in patients with cytomegalovirus or adenovirus that has come back after a stem cell or solid organ transplant.


Eligibility

Min Age: 1 YearMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a biological treatment called Allogeneic Adenovirus-specific Cytotoxic T Lymphocytes and a biological treatment called Allogeneic Cytomegalovirus-Specific Cytotoxic T lymphocytes for people with adenovirus, allogeneic hematopoietic stem cell transplantation recipient, and other related conditions. The study is currently recruiting participants at 2 locations. People eligible for this study include aged 1 Year to 85 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALAllogeneic Cytomegalovirus-Specific Cytotoxic T lymphocytes

Given intravenously

BIOLOGICALAllogeneic Adenovirus-specific Cytotoxic T Lymphocytes

Given intravenously


Locations(2)

Nationwide Children's Hospital

Columbus, Ohio, United States

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, United States

View Full Details on ClinicalTrials.gov

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NCT03665675


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