RESOLVE: Abemaciclib + Letrozole +/- Metformin, Zotatifin, or Gedatolisib in Endometrial or Low-Grade Serous Ovarian Cancer

This trial is testing various combinations of targeted drugs — including abemaciclib, letrozole, metformin, zotatifin, and gedatolisib — for women with endometrial cancer (uterine cancer) or low-grade serous ovarian cancer that has come back or spread after prior treatment. **You may be eligible if...** - You have been diagnosed with recurrent or metastatic endometrial cancer, or low-grade serous ovarian cancer - Your cancer has been confirmed by biopsy - You have had prior standard treatment but your cancer continued to grow or came back - You are in adequate overall health with acceptable organ function **You may NOT be eligible if...** - You have had too many prior chemotherapy regimens (specific limits apply per study group) - You have active brain metastases - You have serious heart problems (such as uncontrolled high blood pressure or a recent heart attack) - You are pregnant or breastfeeding - You are on medications that significantly interact with the study drugs - You have uncontrolled diabetes (for groups including metformin) Talk to your doctor to see if this trial is right for you.