Fractionated Stereotactic Radiotherapy vs. Single Session Radiosurgery in Patients With Larger Brain Metastases

This trial is comparing two approaches for treating brain tumors that have spread from other cancers: a single high-dose radiation session (called radiosurgery) versus several smaller doses given over multiple visits (called fractionated stereotactic radiotherapy), to find out which approach is more effective and better tolerated for larger brain metastases. **You may be eligible if...** - You are over 18 years old - You have 1 to 10 brain metastases from a solid cancer - Your doctor has determined you need radiation treatment for the brain metastases - Your overall health is good enough (Karnofsky score above 50) - Your expected survival is more than 3 months **You may NOT be eligible if...** - You received whole-brain radiation within 6 weeks before starting this trial, or plan to receive it after - The specific brain tumor to be treated has been irradiated before - Your tumor is located in the brainstem - You cannot have an MRI - You are pregnant or breastfeeding - You have a drug, alcohol, or medication abuse problem - You are already enrolled in another clinical trial Talk to your doctor to see if this trial is right for you.