R-VRD Followed by Lenalidomide Maintenance in Patients With Waldenstrom's Macroglobulinemia
A Multicenter Prospective Phase II Study of Rituximab Combined, Lenalidomide, Dexamethasone Followed by Lenalidomide Maintenance in Patients With Newly Diagnosed Waldenström's Macroglobulinemia
Kosin University Gospel Hospital
54 participants
Mar 6, 2019
INTERVENTIONAL
Conditions
Summary
A multicenter prospective phase II study of rituximab combined, lenalidomide, dexamethasone followed by lenalidomide maintenance in patients with newly diagnosed Waldenström's macroglobulinemia (Ballondor trial)
Eligibility
Inclusion Criteria9
- Clinicopathological diagnosis of Waldenstrom's Macroglobulinemia
- Patients who meet criteria for treatment using consensus panel criteria from the Second International Workshop on Waldenstrom's macroglobulinemia
- Male or female patients aged ≥19 years
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- Patients must have measurable disease, IgM > 0.5g/dL
- Appropriate bone marrow, liver, and kidney function
- Patients who are able to understand oral and written instructions and who are able to comply with all requirements
- Patients who provided agreement of subject consent (ICF) prior to initiation of clinical trial.
- Female patients had to be post-menopausal for ≥1 year, surgically sterile, or practicing an effective method of birth control (as described in the protocol), and have a negative serum beta-human chorionic gonadotropin or urine pregnancy test at screening; they also had to agree to continue using birth control measures for ≥6 months after terminating treatment. Male patients had to agree to use an acceptable method of contraception for the duration of the study.
Exclusion Criteria18
- Central nervous system involvement central nervous system (CNS) involvement by Waldenström's macroglobulinemia
- Patients who have received rituximab, lenalidomide, or bortezomib
- Patients who are allergic or hypersensitive to mouse (murine), chimeric, human or humanized proteins, lenalidomide, bortezomib
- One of the following labs or more:
- Absolute neutrophil count (ANC) <1,000 / μL
- Platelet count <75,000 cells / μL when not transfused
- Serum AST / ALT> 3 times the upper limit of normal
- Renal failure requiring hemodialysis or peritoneal dialysis
- Patients with uncontrolled severe heart disease
- Patients who can not or do not want antithrombotic therapy
- Patient has more than Grade 2 peripheral neuropathy on clinical examination during the screening period
- Patient with a history of stroke or cerebral hemorrhage within 12 months bofore signing ICF
- Patients who have been diagnosed with a currently unadjusted severe infection
- Patients with known human immunodeficiency virus (HIV), hepatitis C infection
- Patients diagnosed with malignancy within 5 years before signing ICF
- Pregnant or lactating patients
- Requires treatment with a strong cytochrome P450 (CYP) 3A inhibitor
- Patients with acute diffuse invasive pulmonary disease and cardiovascular disease
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Interventions
step 1; R-VRD induction : rituximab, bortezomib, lenalidomide, and dexamethasone induction * Rituximab 375 mg/m2 intravenous on day 1 * Bortezomib 1.3mg/m2 subcutaneous on day 1, 8, 15 * Lenalidomide 15mg p.o on day 1-21 * Dexamethasone 20 mg/m2 intravenous or p.o on day 1-4 Step 2 ; Maintenance Beginning 8 weeks after completion of induction therapy, patients receive lenalidomide 10mg once day 1-21 for 4 weeks. Treatment repeats every 1 months for 24 months.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT03697356