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RecruitingPhase 1NCT03705715

Identifying Correlates of Brain Microglial Activation in Neuropsychiatric Syndromes: a Dimensional Approach

Sponsor

The University of Texas Health Science Center, Houston

Enrollment

200 participants

Start Date

May 1, 2017

Study Type

INTERVENTIONAL

Conditions

Neuropsychiatric Syndromes

Summary

The purpose of this research is to determine whether there is more extensive inflammation in the brain of people with clinical evidence of neuropsychiatric syndromes, such as mood disorder, chronic pain syndrome, dementia, traumatic brain injury, or substance abuse. The research will also explore whether there is more inflammation in patients with more neuropsychiatric symptoms. Inflammation in the brain will identified by using Positron Emission Tomography (PET) with the radiotracer \[11C\]PBR-28 or \[11C\]ER176.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Inclusion Criteria8

  • Must be between 18-80 years old
  • Males or females
  • Must be right handed
  • Must be able to sit unaccompanied for long periods of time with little body movement
  • Must be illicit drug free at time of scanning as appropriate (UDS negative),
  • Must be either healthy (without medical, neurological, psychiatric illness) or have a diagnosis of a neuropsychiatric syndrome (mood disorder, chronic pain syndrome, dementias, traumatic brain injury, substance/alcohol use disorder).
  • Healthy Control volunteers must be medication free (≥ 14 days)
  • Illicit drug free at time of scanning (verified by negative urine drug screen)

Exclusion Criteria5

  • Must not be a smoker.
  • Females must not be pregnant or nursing.
  • Must not suffer from claustrophobia
  • Must not be PBR-28 low affinity binder (or using the \[11C\]ER176 study radiotracer)
  • Healthy control volunteers must not have on-going, chronic, or relapsing/remitting medical, psychiatric (absence of both DSM-IV Axis I and/or Axis II disorders), or neurological illness as determined by combination of history, medical record, and/or examination.

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Interventions

DRUGPET with radiotracer [11C]PBR-28 ( or [11C]ER176)

\[11C\]PBR-28 or \[11C\]ER176 will be injected into subjects' veins during PET scanning.

OTHERAffective challenge

Affective challenge is the induction of, for example, mood or affective pain.

Locations(1)

BBSB at UTHealth

Houston, Texas, United States

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NCT03705715