RecruitingNCT03716128
Diagnosis of Renal Osteodystrophy in Patients With Reduced Renal Function
Diagnosis of Renal Osteodystrophy in Patients With Reduced Renal Function Can 18F-PET Replace Bone Histomorphometry
Sponsor
Ditte Hansen
Enrollment
40 participants
Start Date
Sep 26, 2018
Study Type
OBSERVATIONAL
Conditions
Summary
The aim of the study is to 1. To describe the bone morphology in patients with reduced renal function and high or low parathyroid hormone (PTH) respectively. 2. To investigate if the non-invasive method 18-Fluoride Positron Emission Tomography (18F-PET) can describe the bone turnover and reflect the bone histomorphologic changes 3. To investigate if non-oxidized PTH reflects bone turnover
Eligibility
Min Age: 18 Years
Inclusion Criteria8
- Patients with reduced renal function:
- ≥ 18 years
- estimated Glomerular Filtration Rate (eGFR) ≤ 20 ml/min/1,73m2
- PTH \< 150 pg/ml or PTH \> 300 pg/ml
- ≥ 18 years
- eGFR \>= 60 ml/min
- under examination for c prostata
- Prostatic Specific Antigen (PSA) total \<40 µg/l
Exclusion Criteria9
- ongoing malignancy
- Allergy towards tetracyclin
- Pregnancy
- Control Group:
- Former kidney disease
- ionized calcium or PTH outside normal range
- Known metabolic bone disease
- treatment with anticoagulants
- Disturbed thrombosis and hemostasis
Interventions
DIAGNOSTIC_TEST18F-PET
Bone biopsy and 18F-PET
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT03716128