RecruitingPhase 2NCT03727633

Hepatocellular Carcinoma on Cirrhosis With Child A/B7 and Hepatic Intra Arterial Injection of Idarubicin/Lipiodol Emulsion

Traitement Des Carcinomes hépatocellulaires Sur Cirrhose Child A/B7 Par Injection Intra-artérielle hépatique d'Une émulsion de Lipiodol et Idarubicine : Etude de Phase II, Monobras, Multicentrique.


Sponsor

University Hospital, Montpellier

Enrollment

53 participants

Start Date

Jul 19, 2018

Study Type

INTERVENTIONAL

Conditions

Summary

The investigators propose in this trial to test a hepatic chemotherapy, consisting of the hepatic intra-arterial injection Idarubicin, emulsified with Lipiodol, lipid vector, without embolization in the treatment of non-metastatic, unresectable hepatocellular carcinoma on cirrhosis with Child-Pugh A/B7.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is studying a treatment that delivers chemotherapy directly into the liver's blood supply for people who have liver cancer (hepatocellular carcinoma) that cannot be surgically removed. **You may be eligible if...** - You have been diagnosed with liver cancer (confirmed by biopsy or imaging) - Your liver function is relatively preserved (Child-Pugh A or B7 score) - Your cancer cannot be removed by surgery, ablation, or other local treatments - You are in reasonably good physical condition (ECOG performance status 0 or 1) - You are 18 years or older - You have not previously received chemotherapy, radiation, or other liver-directed treatments for this cancer **You may NOT be eligible if...** - You have already received chemotherapy, radiation, or liver-directed treatments for this cancer - Your liver function is severely impaired (Child-Pugh C) - You have very low platelet counts (below 50,000) - Your overall health makes you unsuitable for the procedure Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGIdarubicin and Lipiodol

Hepatic intra-arterial chemotherapy consisting of the hepatic intra-arterial injection Idarubicin, emulsified with Lipiodol


Locations(4)

CHU d'Angers

Angers, France

CHU de Dijon

Dijon, France

CHU de Montpellier

Montpellier, France

CHU de Nice

Nice, France

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NCT03727633


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