Characterizing Disease Biology, Treatment and Toxicity in Older Adults With Hepatocellular Carcinoma

This study is collecting detailed information on older adults newly diagnosed with advanced liver cancer (hepatocellular carcinoma, or HCC). Researchers want to understand how age, overall physical health, existing medical conditions, and treatment choices affect outcomes — since older adults are often underrepresented in clinical trials, yet make up a large share of HCC diagnoses. **You may be eligible if...** - You are 18 or older (with a particular focus on older adults) - You have been newly diagnosed with hepatocellular carcinoma confirmed by biopsy or imaging (CT or MRI) - Your cancer is advanced and cannot be surgically removed, as determined by your treating physician - You have not yet received any prior systemic or localized treatment for HCC **You may NOT be eligible if...** - Your liver cancer can still be surgically removed or treated with localized therapy options - You have already begun systemic or locoregional treatment for your HCC Talk to your doctor to see if this trial is right for you.