STep-up and Step-down Therapeutic Strategies in Childhood ARthritiS

This trial is studying the best order of treatment steps — starting with stronger medications first versus starting with milder ones — for children newly diagnosed with a form of juvenile arthritis (JIA). **You may be eligible if...** - Your child has been newly diagnosed with juvenile idiopathic arthritis (specifically the oligoarthritis or rheumatoid factor negative polyarthritis type) - Your child has not yet been treated with disease-modifying drugs (DMARDs) or biologics (only one NSAID pain reliever is allowed) - Your child's arthritis symptoms started no more than 6 months ago - Your child's joints are currently actively inflamed **You may NOT be eligible if...** - Your child has already received disease-modifying or biologic medications - Your child's arthritis started more than 6 months before enrollment - Your child has a different type of juvenile arthritis not covered by this study - Your child has had steroid injections into joints before enrollment Talk to your doctor to see if this trial is right for you.