A Multi-Modality Surveillance Program for Women at High Risk for Breast Cancer

This trial is studying an enhanced screening program using multiple imaging methods to detect breast cancer early in women who are at very high risk for developing the disease due to genetic mutations or other risk factors. **You may be eligible if...** - You carry a known high-risk gene mutation (such as BRCA1, BRCA2, TP53, PALB2, PTEN, CDH1, or STK11) - Your lifetime risk of breast cancer is 30% or higher based on genetic and non-genetic risk scores - Your 5-year risk of breast cancer is 6% or higher (for women aged 40–64 or 65+) - Women 65+ may also qualify with dense breast tissue and a lifetime risk of 20% or more - You are female and have not had breast cancer **You may NOT be eligible if...** - You have a personal history of breast cancer - You do not meet the high-risk genetic or statistical criteria above - You are unable to undergo MRI or other imaging Talk to your doctor to see if this trial is right for you.