Determine Immunoglobulin G4 (IgG4) Standards for Cow's Milk and Egg in Different Populations of Allergic and Non-allergic Children
Assistance Publique - Hôpitaux de Paris
500 participants
Nov 18, 2020
OBSERVATIONAL
Conditions
Summary
The study objectives are : Determine standards of plasma levels of casein-specific immunoglobulin G4 (IgG4) and egg-specific immunoglobulin G4 (IgG4) as a function of age, in non-allergic children, in allergic children, and in cured former allergic patients. Analyze the plasma IgG4 / IgE ratio, according to the result of the oral provocation test (tolerance versus allergy) and, in the event of a reaction, according to the reactogenic dose (dose which caused the reaction).Determine whether analysis of the plasma metabolome can identify children with a cured allergy to cow's milk protein or to egg from those with a persistent allergy.
Eligibility
Inclusion Criteria3
- Minors aged 0 to 18
- In consultation or hospitalized for an oral food challenge for milk or eggs
- To undergo a blood test
Exclusion Criteria1
- Minors with immune deficiency, chronic inflammatory disease or immunosuppressive or immunomodulator treatment
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Interventions
Patients less than 5 kg : 2 ml Patients over 5 kg : 3 ml Patients over 10 kg : 5 ml
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT03776474