Enhancing Renal Graft Function During Donor Anesthesia
Renal Graft Functional Enhancement During Donor Anesthesia: A Comparative Study of 3 Modalities
Nazmy Edward Seif
60 participants
Dec 20, 2018
INTERVENTIONAL
Conditions
Summary
Renal transplantation is now recognized as the treatment of choice for patients with end-stage renal disease. An optimum anesthetic regimen should enhance the function and perfusion of the transplanted kidney. The aim of this study is to assess \& compare the effectiveness of 3 different modalities in this respect: Mannitol, Dopamine and adequate hydration.
Eligibility
Inclusion Criteria1
- end-stage renal disease, for living-donor kidney transplantation
Exclusion Criteria2
- severe cardiac or hepatic dysfunction
- coagulopathy
Interventions
Infusion of Mannitol 20% at a dose of 0.5 mg/kg to the renal graft donor after induction of anesthesia over 15 minutes.
Infusion of Dopamine at a dose of 4 microg/kg/min to the renal graft donor after induction of anesthesia till ligation of the renal artery.
Infusion of Ringer Acetate at a rate of 15 ml/kg/hr to the renal graft donor after induction of anesthesia till ligation of the renal artery.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT03778944