Effects of Opioids and NSAIDs on Sympathetic Nervous System and Vascular Function
Effect of Opioids and NSAIDs on Sympathetic Nervous System and Vascular Function in Healthy Subjects and Patients With Osteoarthritis
University of Zurich
90 participants
Jan 1, 2019
INTERVENTIONAL
Conditions
Summary
Evaluation of the effect of different analgesic treatments (Tramadol, Paracetamol, Diclofenac) on sympathetic nerve activity, blood pressure, heart rate, heart rate, and vascular function in osteoarthritis patients and healthy subjects.
Eligibility
Inclusion Criteria2
- Patients ≥ 18 years of age, male or female, with a diagnosis of osteoarthritis or healthy subjects ≥ 18 years of age;
- Written informed consent;
Exclusion Criteria10
- History of hypersensitivity or allergy to any of the study drugs
- Acute coronary syndrome, stroke, transient ischemic attack, cardiac, carotid or other major CV surgery, percutaneous coronary intervention (PCI) or carotid angioplasty within the 3 months prior to Visit 1;
- Coronary or carotid artery disease likely to require surgical or percutaneous intervention within the 3 months after Visit 1;
- Presence of significant endocrine diseases;
- Presence of active acute infectious diseases;
- Known narrow-angle glaucoma;
- Known epilepsy;
- Cimino-shunt operation on both arms;
- Pregnancy, intention thereof during study, lack of sufficient contraception, breastfeeding;
- Drug or alcohol abuse;
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Interventions
A single i.v. infusion of Tramadol (dose: 400mg/100ml) will be administered to the participants (treatment arm).
A single i.v. infusion of Paracetamol (dose: 1g/100ml) will be administered to the participants (control arm).
A single i.v. infusion of Diclofenac (dose: 75mg/100ml) will be administered to the participants (treatment arm).
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT03781544