RecruitingNot ApplicableNCT03785574

Study of Different Therapeutic Strategies in Hydatidiform Mole With Lung Nodule

Study of Different Therapeutic Strategies in Hydatidiform Mole With Lung Nodule,A Prospective Multicentre Randomized Controlled Trial


Sponsor

Women's Hospital School Of Medicine Zhejiang University

Enrollment

30 participants

Start Date

Dec 24, 2018

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of present study is to provide clinical evidences for the appropriate management of molar pregnancy with lung nodule. The hydatidiform mole patients with lung nodule ≥1.0cm will be randomized into 2 groups: A. treated with chemotherapy immediately, B. follow up until hCG level met FIGO diagnostic criteria of GTN (B1) or hCG level declined to normal spontaneously (B2). Lung nodule \<1.0cm will directly treated as group C


Eligibility

Sex: FEMALEMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing different treatment approaches for patients who have a molar pregnancy (an abnormal growth in the uterus that forms instead of a normal pregnancy) and also have spots or nodules detected on their lungs. Researchers want to find out which strategy best resolves the condition while avoiding unnecessary treatment. **You may be eligible if...** - You have been diagnosed with a molar pregnancy (hydatidiform mole) confirmed by biopsy - Lung nodules have been detected on a CT scan and cannot yet be ruled out as spread of disease - Your blood hormone (hCG) levels do not yet meet the threshold for a formal cancer diagnosis - You are willing to participate and provide informed consent **You may NOT be eligible if...** - Your molar pregnancy has already been confirmed as malignant with clear metastatic spread - You have already received treatment for gestational trophoblastic disease - You do not meet specific lab or imaging criteria Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERFollow up

the follow up group would be naturely didived into 2 subgroups depending the hCG regression degree.

DRUGchemotherapy

First line treatments:low risk:Methotrexate or ACTD; high risk:EMA-CO


Locations(1)

Weiguo Lv

Hangzhou, Zhejiang, China

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NCT03785574


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