RecruitingNCT03793062
Genetic and Epigenetic Basis of Chronic Wounds
Sponsor
University of Pittsburgh
Enrollment
256 participants
Start Date
Dec 4, 2018
Study Type
OBSERVATIONAL
Summary
This pilot study is designed for chronic wounds that fail to heal in a timely manner carry specific genetic signatures. These genetic signatures will be studied using debrided wound tissue that is removed by the wound care provider as part of standard of care. The reference genomic signature will be evaluated by obtaining blood samples and will be compared with wound debrided tissue genomic signature to understand wound specific genomic changes.
Eligibility
Min Age: 18 YearsMax Age: 100 Years
Inclusion Criteria5
- Age ≥ 18 years
- Willing to comply with protocol instructions, including all study visits and study activities.
- Chronic wounds (> than four weeks since onset)
- Clinically diagnosed diabetic or non-diabetic ulcer.
- For patients with multiple wounds, the largest wound will be used for the study.
Exclusion Criteria4
- Individuals who are deemed unable to understand the procedures, risks and benefits of the study,(i.e. unable to provide informed consent)
- Pregnant females (self-declared) or lactating
- Subjects with marked immunodeficiency (HIV/AIDS or immune-suppressive medications)
- Prisoners
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Interventions
OTHERNo Interventions
Not applicable - No Interventions
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT03793062