Fecal Microbiota Transplantation for Ulcerative Colitis

This trial is testing whether a "fecal microbiota transplant" (FMT) — transferring healthy gut bacteria from a donor into a patient's colon — can help treat moderate to severe ulcerative colitis, a chronic bowel disease that causes inflammation and sores in the colon. **You may be eligible if...** - You have been diagnosed with active, moderate to severe ulcerative colitis - Your condition has been assessed using a standard scoring system (Mayo score above 6) - You have previously used a medication called 5-ASA (a common ulcerative colitis drug) - You are able to undergo a scope procedure (endoscopy) to examine your colon **You may NOT be eligible if...** - You have taken antibiotics in the past 7 days - You have signs of a life-threatening complication called toxic megacolon (extreme colon swelling) - You have colon cancer or pre-cancerous tissue - You have another serious illness affecting the heart, lungs, gut, or kidneys Talk to your doctor to see if this trial is right for you.