Fecal Microbiota Transplantation for Ulcerative Colitis
Efficacy and Safety of Fecal Microbiota Transplantation for Ulcerative Colitis
Guangzhou First People's Hospital
120 participants
Jan 20, 2019
INTERVENTIONAL
Conditions
Summary
Fecal microbiota transplantation (FMT) is a strategy that infuses a fecal suspension containing a healthy donor's microbiota into a patient's gut to restore his/her intestinal microbiome. Fecal microbiota transplantation has been used for several disease，but the efficacy of ulcerative colitis(UC) by fecal microbiota transplantation needs to be further explored.The investigators propose to determine the efficiency and safety of FMT in patients with ulcerative colitis(UC).
Eligibility
Inclusion Criteria3
- Active, moderate to severe severity (Mayo score more than 6)
- Safety using history of 5-ASA
- Able to undergo endoscopy examination
Exclusion Criteria4
- Antibiotic using in 7 days
- High risk of toxic megacolon
- Colon cancer or neoplasia in pathophysiology
- Other severe diseases (eg: cardiovascular, respiratory, gastroenteral and kidney diseases)
Interventions
200 mL of prepared fecal microbiota suspension from healthy donors' fresh feces was injected into the intestine
Infusion of Saline
Mesalazine and/or Prednisone
Locations(1)
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NCT03804931