RecruitingNCT03806283

Mechanisms of Pregnancy Vascular Adaptations

Angiotensin 2 Receptor (AT2R) Expression/Activation in Endothelial Cells in Preeclampsia

Sponsor

University of Wisconsin, Madison

Enrollment

166 participants

Start Date

Nov 20, 2018

Study Type

OBSERVATIONAL

Conditions

Pre-Eclampsia Vascular Diseases

Summary

The investigators will collect omental tissue (research surgical excision) and placental tissue (standard of care clinical delivery) from both preeclamptic and non-preeclamptic women during their c-section and use these samples to study the blood vessels, specifically the expression/activation of the AT2R.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 40 Years

Inclusion Criteria4

Female
Ages 18 to 40 years old
Singleton gestation between 28 weeks, 0 days and 41 weeks, 0 days gestational age at the time of consent
Undergoing caesarean section, either planned or otherwise with or without trial of labor

Exclusion Criteria4

Treatment of severe hypertension by antihypertensive or use of magnesium sulfate after the patient is hospitalized for the diagnosis of preeclampsia.
Any major fetal structural anomalies or aneuploidies
Undergoing cesarean section for placental abruption or bleeding complications.
Singleton gestation not within 36 weeks, 0 days and 41 weeks, 0 days gestational age at the time of enrollment (delivery)

Interventions

PROCEDUREOmental Biopsy

The surgeon and clinical care team will conduct the c-section to deliver the baby and the placenta as clinically indicated. After delivery, during the closing procedures, the surgeon will indicate a time for a participating Ob/Gyn physician on the study team to collect the omental bio-specimen. Omentum is frequently excised or removed for clinical reasons during surgical procedures. Omentum has small blood vessels within it that have been used for evaluation of vascular functional changes in research. The investigators wish to isolate one to three vessels of 5 to 7 cm length. The surgeon will then close and the clinical care team will resume their standard of care activities.