Trial of Acetylsalicylic Acid and Atorvastatin in Patients With Castrate-resistant Prostate Cancer

This trial is testing whether two common, inexpensive medications — aspirin (acetylsalicylic acid) and atorvastatin (a cholesterol-lowering drug, commonly known as a statin) — can slow the progression of prostate cancer that is no longer responding to hormone-blocking therapy (called castrate-resistant prostate cancer, or CRPC). **You may be eligible if...** - You have been diagnosed with prostate cancer that has stopped responding to hormone therapy (castrate-resistant prostate cancer, or CRPC) - Your testosterone levels are very low (confirmed by blood test) - You are 18 years or older with a life expectancy of at least 6 months - Your cancer is progressing (rising PSA or changes on imaging) despite hormone therapy - You have not yet received life-prolonging CRPC treatments like abiraterone, enzalutamide, or docetaxel **You may NOT be eligible if...** - You have already received specific advanced prostate cancer treatments (abiraterone, enzalutamide, radium-223, docetaxel, etc.) - You cannot safely take aspirin or statins due to other health conditions Talk to your doctor to see if this trial is right for you.