MRI-targeted Biopsy of the Prostate: Software Versus Visual Registration in the Accuracy of Prostate Cancer Detection

This trial is comparing two methods of using MRI images to guide prostate biopsies — one using specialized computer software and one using a doctor's visual judgment — to see which approach more accurately finds prostate cancer. **You may be eligible if...** - You are a man between 50 and 75 years old - You have a clinical suspicion of prostate cancer (elevated PSA blood test or abnormal rectal exam) - Your prostate MRI has shown a suspicious area (rated PI-RADS 3 to 5) - You have not previously had a prostate biopsy or prostate cancer diagnosis - You are in generally good health **You may NOT be eligible if...** - You have already been diagnosed with prostate cancer - You have had a prostate biopsy before - You cannot have an MRI (for example, due to claustrophobia or certain metal implants) - Your MRI or CT scan shows cancer has spread to lymph nodes or bones - You have a hip replacement or pelvic metal implant that interferes with MRI Talk to your doctor to see if this trial is right for you.