RecruitingPhase 4NCT03826524

Epinephrine Dose: Optimal Versus Standard Evaluation Trial

CanROC Epinephrine Dose: Optimal Versus Standard Evaluation Trial (CanROC EpiDOSE Trial)

Sponsor

Unity Health Toronto

Enrollment

3,790 participants

Start Date

May 24, 2023

Study Type

INTERVENTIONAL

Conditions

Ventricular Fibrillation Sudden Cardiac Arrest Cardiac Arrest, Out-Of-Hospital Ventricular Tachycardia-Pulseless

Summary

The objective of this randomized controlled trial is to evaluate the effectiveness of a low cumulative dose of epinephrine compared to a standard cumulative dose of epinephrine during resuscitation from ventricular fibrillation (VF) or ventricular tachycardia (VT) in adult out-of-hospital cardiac arrest (OHCA) patients.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

Out-of-hospital cardiac arrest treated by paramedics
Initial recorded cardiac rhythm of VF or pulseless VT, or, AED shock on first analysis administered or witnessed by EMS (paramedic or fire)
Established intravenous vascular access

Exclusion Criteria6

Known or apparent age \<18 years
Initial recorded cardiac rhythm of VF or pulseless VT, or, AED shock on first analysis administered or confirmed by paramedics
Cardiac arrest due to an obvious non-cardiac primary cause (e.g. blunt or penetrating trauma, exsanguination, burns, drug overdose, drowning, anaphylaxis, sudden asphyxiation, etc.)
Administration of intramuscular, endotracheal tube, or intraosseous epinephrine
Prisoners or persons in police custody
Known allergy or sensitivity to epinephrine

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Interventions

DRUGEpinephrine

Epinephrine 1mg 1:10000 (10cc) per dose

Locations(8)

British Columbia Emergency Health Services (BCEHS)

Victoria, British Columbia, Canada

Peel Regional Paramedic Services

Brampton, Ontario, Canada

Middlesex-London Paramedic Service

London, Ontario, Canada

Halton Region Paramedic Services

Oakville, Ontario, Canada

Ottawa Paramedic Services

Ottawa, Ontario, Canada

Superior North Emergency Medical Services

Thunder Bay, Ontario, Canada

Essex-Windsor Emergency Health Services

Windsor, Ontario, Canada

Medavie Health Services West

Saskatoon, Saskatchewan, Canada

View Full Details on ClinicalTrials.gov

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NCT03826524

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