RecruitingNot ApplicableNCT03829033

Photon Therapy Versus Proton Therapy in Early Tonsil Cancer.


Sponsor

Lund University Hospital

Enrollment

100 participants

Start Date

Jan 22, 2019

Study Type

INTERVENTIONAL

Conditions

Summary

In this trial, patients with early squamous cell carcinoma of the tonsil with clinical stage T1-2 (p16-positive or p16-negative) N0-1 (p16-positive)/N0-N2b (p16-negative) according to American Joint Committee on Cancer (AJCC) 8th edition, aimed for unimodal and ipsilateral treatment with radiotherapy with curative intent will be included. The patients will be randomized to in a 1:1 ratio to receive radiotherapy with either photons (conventional radiotherapy) versus radiotherapy with protons.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is comparing standard photon radiation (traditional X-ray based radiation therapy) with proton therapy (a newer, highly targeted type of radiation that delivers energy precisely to the tumor with less exposure to surrounding healthy tissue) in patients with early-stage tonsil cancer. **You may be eligible if...** - You are at least 18 years old - You have been diagnosed with squamous cell carcinoma of the tonsil (a specific type of throat cancer) that has been confirmed by tissue sampling - Your cancer has not spread widely (classified as T1-2, N0-N2b, M0 depending on your tumor's HPV/p16 status) - Your cancer has not been treated before with radiation - Your radiation treatment is aimed at cure, targeting only one side of the throat - You are in generally good health (WHO/ECOG performance score 0-1) **You may NOT be eligible if...** - Your cancer has already spread to distant parts of the body - You have received prior radiation to this area - Your cancer is too advanced for targeted one-side radiation therapy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONRadiotherapy

Radiotherapy with either photons or protons.


Locations(12)

Gävle Hospital

Gävle, Sweden

Sahlgrenska University Hospital

Gothenburg, Sweden

Jönköping Hospital

Jönköping, Sweden

Karlstad Hospital

Karlstad, Sweden

Linköping University Hospital

Linköping, Sweden

Lund University Hospital

Lund, Sweden

Örebro University Hospital

Örebro, Sweden

Karolinska University Hospital

Stockholm, Sweden

University Hospital

Umeå, Sweden

Scandion clinic

Uppsala, Sweden

Uppsala Accademical Hospital

Uppsala, Sweden

Västmanlands Hospital

Västerås, Sweden

View Full Details on ClinicalTrials.gov

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NCT03829033


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