CD4CAR for CD4+ Leukemia and Lymphoma

This study is testing a new type of immune cell therapy called CD4CAR — where doctors reprogram your own immune cells to attack a specific kind of blood cancer — in people whose cancer has not responded to standard treatments. **You may be eligible if...** - You are 12 years old or older - You have been diagnosed with a blood cancer involving a type of immune cell called a CD4+ T cell (such as certain leukemias or lymphomas) - Your cancer has come back or stopped responding to chemotherapy or a previous bone marrow transplant - Your heart, kidneys, and liver are functioning well enough to handle the treatment - You do not need extra oxygen while resting **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have an active, uncontrolled infection - You have active hepatitis B or C - You are HIV positive - You have an active autoimmune disease requiring ongoing treatment - You have received another experimental cell or gene therapy in the past 6 months - You have another cancer (besides the T-cell cancer) that required treatment in the last 3 years - You take high-dose steroids on an ongoing basis Talk to your doctor to see if this trial is right for you.