Sequential Transplantation of UCBSCs and Islet Cells in Children and Adolescents With Monogenic Immunodeficiency T1DM

This study is testing a treatment that combines two types of transplants — donated cord blood stem cells and donated insulin-producing islet cells from the pancreas — to help children with Type 1 diabetes who also have a rare genetic immune system condition that causes damage to multiple organs. **You may be eligible if...** - You are a child diagnosed with Type 1 diabetes AND a genetic immune deficiency (confirmed by gene testing) that is causing damage to multiple organs (such as the gut, kidneys, liver, or joints) - Your symptoms keep returning despite standard medical treatment - You do not have a well-established, effective treatment option currently available **You may NOT be eligible if...** - A proven, effective treatment already exists for your condition - You are HIV positive, or have active hepatitis B or C - You currently have an active infection - You have an active malignant (cancerous) tumor - You have another life-threatening disease alongside this one Talk to your doctor to see if this trial is right for you.