RecruitingNCT03849963

Imaging Oxidative Metabolism and Neurotransmitter Synthesis in the Human Brain

Sponsor

University of Texas Southwestern Medical Center

Enrollment

28 participants

Start Date

Jul 30, 2030

Study Type

OBSERVATIONAL

Conditions

Brain Metabolism

Summary

Investigators propose to develop hyperpolarized \[13C\]-labeled pyruvate as potential imaging probes to assess two essential in vivo processes in cerebral metabolism: oxidative metabolism and synthesis of a neurotransmitter in this observational study.

Eligibility

Min Age: 18 YearsMax Age: 60 Years

Inclusion Criteria4

through 60 years of age.
Healthy, with no neurological abnormalities.
Ability to understand and the willingness to sign a written informed consent.
All races and ethnicities will be included; subjects must be able to read and speak the English language.

Exclusion Criteria14

Metallic foreign bodies on the scalp or cranium which may interfere with MRI acquisitions
Major debilitating neurological disease including, but not limited to, stroke, CVA, dementia and tumor that would limit compliance with study requirements
Under influence of illicit drugs which are known to alter brain physiology/metabolism including, but not limited to cocaine, lysergic acid diethylamide (LSD), and marijuana at the time of MRI/MRSI scanning.
Under influence of antiepileptic drugs at the time of MRI/MRSI scanning.
Any contraindication per MRI Screening Form including
Implants contraindicated at 3T, pacemakers
Implantable Cardioverter Defibrillator (ICD)
Claustrophobia
Medically unstable including
Heart failure
Severe left ventricular outflow tract (LVOT) obstruction
Unstable angina
Pregnancy
Lactating

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Locations(1)

UT Southwestern - Advanced Imaging Research Center

Dallas, Texas, United States

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NCT03849963