Molecular Detection of Advanced Neoplasia in Pancreatic Cysts

This study is testing whether analyzing fluid and tissue samples taken from pancreatic cysts (fluid-filled sacs in the pancreas) during a routine procedure can help identify which cysts are likely to turn cancerous, in order to guide better surgical and monitoring decisions. **You may be eligible if...** - You have pancreatic cysts that meet specific concerning criteria (called Fukuoka worrisome features or high-risk stigmata) on imaging - You are suspected to have a cystic (fluid-filled) tumor of the pancreas - You are able to give written informed consent **You may NOT be eligible if...** - You are pregnant or breastfeeding - You are incarcerated - Imaging already suggests an existing pancreatic cancer - You have a prior history of pancreatic cancer or previous pancreatic surgery - You have received chemotherapy or abdominal radiation in the past 5 years - You have had a previous procedure to treat a pancreatic cyst - You have a history of pancreatic necrosis (tissue death in the pancreas) - You have had a cancer diagnosis (other than non-melanoma skin cancer) in the past 5 years Talk to your doctor to see if this trial is right for you.