RecruitingPhase 3NCT03859921

Oral Dydrogesterone as Luteal Phase Support in Natural Cycle FET

A Randomized Double Blind Controlled Comparison of Oral Dydrogesterone as Luteal Phase Support in Natural Cycle Frozen-thawed Embryo Transfer


Sponsor

The University of Hong Kong

Enrollment

716 participants

Start Date

Jul 1, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

This randomised double-blinded controlled trial aims to compare the live birth rate in natural FET cycles with and without oral dydrogesterone as luteal phase support. The hypothesis is that the use of oral dydrogesterone will increase the live birth rate of natural cycle FET.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 42 Years

Inclusion Criteria2

  • Age of women \<43 years at the time of stimulated IVF
  • Replacing early cleavage embryos or blastocysts after thawing

Exclusion Criteria5

  • Requiring hormonal replacement cycles
  • Use of donor oocytes or embryos
  • Undergoing preimplantation genetic testing
  • Presence of hydrosalpinx not corrected surgically prior to FET
  • Refusal to join the study

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Interventions

DRUGDydrogesterone

Progesterone

DRUGPlacebo

Placebo with appearance similar to Dydrogesterone


Locations(1)

Department of Obstetrics and Gynaecology

Hong Kong, Hong Kong, China

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NCT03859921


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