Image-guided Focal Brachytherapy Utilizing Combined 18F-DCFPyl PET/CT

This study is testing a targeted internal radiation approach called focal brachytherapy — which delivers radiation only to the specific area of the prostate where cancer has been confirmed using a special PET scan (PSMA PET) and MRI — for men with low-to-intermediate risk prostate cancer, with the aim of treating the cancer while minimizing damage to surrounding healthy tissue. **You may be eligible if...** - You have been diagnosed with prostate adenocarcinoma - Your cancer is early-stage (T1c or T2a), with no known lymph node or distant spread - Your Gleason score is 6 or 7 (low to intermediate risk) - Your prostate is not too large (under 60cc) - Your urinary symptoms are not severe (IPSS score 20 or below) - You are able to undergo the PSMA PET scan for staging purposes **You may NOT be eligible if...** - You have previously had pelvic radiation therapy - You have metal implants or claustrophobia that prevent MRI - You have had another cancer in the past 3 years - You have implanted devices that would block visibility of implanted radiation sources during the procedure - You have major medical or psychiatric conditions that would prevent completing treatment Talk to your doctor to see if this trial is right for you.