RecruitingNot ApplicableNCT03865771

Sleep Related Memory Consolidation in Children With Age Related Focal Epilepsy.


Sponsor

University Hospital, Strasbourg, France

Enrollment

95 participants

Start Date

Mar 27, 2019

Study Type

INTERVENTIONAL

Conditions

Summary

Age related focal epilepsies in children encompasses, according to the ILAE criteria, benign epilepsy with centro temporal spikes (BECTS), atypical benign partial epilepsy (ABPE) and epileptic encephalopathy with continuous spike and waves during sleep (ECSWS). These non structural epilepsies are associated with interictal sleep spike and waves activated by sleep. Moreover, high prevalence of learning disorders occur in children with age related epilepsies. A correlation is suspected between learning disorders and sleep activation of spike and waves. The investigators suppose that learning dysfunction is linked to loss of information during sleep of epileptic children, unlike for control patients. As sleep allows memory consolidation of words learned during wakefulness, an epileptic activity during sleep may disrupt this consolidation, leading to a loss of information. Hypothesis: the investigators hypothesize a disruption of memory consolidation after one night in children affected with ABPE and ECSWS (severe group) compared to memory consolidation in children affected with BECTS (benign group), and control group. Primary purpose: To demonstrate that the deficit of delayed recall in 15 word learning test after one night is higher for the "severe group", compared to the "benign group" and the control group. Secondary purposes: * to study the evolution over time of memory consolidation * to evaluate the correlation of the deficit of delayed recall with executive dysfunction, clinical factors of epilepsy, neurophysiological factors of epilepsy, and sleep architecture


Eligibility

Min Age: 6 YearsMax Age: 13 Years

Inclusion Criteria11

  • Principal:
  • normal psychomotor development
  • informed consent signed by both parents and subject if able
  • affiliated to social security regimen
  • Specific
  • Patients from "severe" and "benign" groups:
  • focal age related epilepsy: BECTS, ABPE, ECSWS (ILAE criteria)
  • children hospitalized for their follow-up
  • normal neuroimaging
  • Control group
  • children hospitalized for a non neurologic disease

Exclusion Criteria11

  • Principal:
  • Psychiatric trouble (DSM V) Sensorial trouble without correction Poor command of French language Minor under care
  • Specific
  • Patients from "severe" and "benign" groups:
  • degenerative disease
  • abnormal neuroimaging
  • mental deficiency
  • Control group
  • neurologic trouble
  • abnormal sleep EEG
  • intellectual deficiency

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

BEHAVIORALNeuropsychological testing

memory, executive testing, behaviour questionnaire, visual attention,

BEHAVIORALNeuropsychological procedure

Rey auditory verbal learning test, Delayed recall : 1h, 5h, 24h (after one night sleep)

OTHERVideo EEG and polysomnography

Video EEG : 10 electrodes + 3 electrodes for PSG 2h wake EEG Whole night EEG


Locations(2)

Hopital D'Enfants Pediatrie Medicale Ambulatoire

Nancy, France

Hopital de Hautepierre-Service de Pediatrie/Neurologie

Strasbourg, France

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT03865771