RecruitingNot ApplicableNCT03865771

Sleep Related Memory Consolidation in Children With Age Related Focal Epilepsy.


Sponsor

University Hospital, Strasbourg, France

Enrollment

95 participants

Start Date

Mar 27, 2019

Study Type

INTERVENTIONAL

Conditions

Summary

Age related focal epilepsies in children encompasses, according to the ILAE criteria, benign epilepsy with centro temporal spikes (BECTS), atypical benign partial epilepsy (ABPE) and epileptic encephalopathy with continuous spike and waves during sleep (ECSWS). These non structural epilepsies are associated with interictal sleep spike and waves activated by sleep. Moreover, high prevalence of learning disorders occur in children with age related epilepsies. A correlation is suspected between learning disorders and sleep activation of spike and waves. The investigators suppose that learning dysfunction is linked to loss of information during sleep of epileptic children, unlike for control patients. As sleep allows memory consolidation of words learned during wakefulness, an epileptic activity during sleep may disrupt this consolidation, leading to a loss of information. Hypothesis: the investigators hypothesize a disruption of memory consolidation after one night in children affected with ABPE and ECSWS (severe group) compared to memory consolidation in children affected with BECTS (benign group), and control group. Primary purpose: To demonstrate that the deficit of delayed recall in 15 word learning test after one night is higher for the "severe group", compared to the "benign group" and the control group. Secondary purposes: * to study the evolution over time of memory consolidation * to evaluate the correlation of the deficit of delayed recall with executive dysfunction, clinical factors of epilepsy, neurophysiological factors of epilepsy, and sleep architecture


Eligibility

Min Age: 6 YearsMax Age: 13 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a behavioral approach called Neuropsychological procedure, a behavioral approach called Neuropsychological testing, and others for people with atypical benign partial epilepsy (abpe), benign epilepsy with centro temporal spikes (bects), and other related conditions. The study is currently recruiting participants at 2 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALNeuropsychological testing

memory, executive testing, behaviour questionnaire, visual attention,

BEHAVIORALNeuropsychological procedure

Rey auditory verbal learning test, Delayed recall : 1h, 5h, 24h (after one night sleep)

OTHERVideo EEG and polysomnography

Video EEG : 10 electrodes + 3 electrodes for PSG 2h wake EEG Whole night EEG


Locations(2)

Hopital D'Enfants Pediatrie Medicale Ambulatoire

Nancy, France

Hopital de Hautepierre-Service de Pediatrie/Neurologie

Strasbourg, France

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NCT03865771