RecruitingNCT03922893

Discovering New Genetic Markers in Adults and Children Who May Be At Risk for Hereditary Forms of Cancer

Discovery and Characterization of Susceptibility Genes in Adults and Children With Suspected Hereditary Cancer Predisposition

Sponsor

Memorial Sloan Kettering Cancer Center

Enrollment

1,500 participants

Start Date

Apr 17, 2019

Study Type

OBSERVATIONAL

Conditions

Cancer

Summary

This study is being done to attempt to identify genetic mutations or other gene-based variations in adults and children who have cancer, or are likely to develop an inherited form of cancer, and potentially reduce their risk for cancer or treat the cancer earlier.

Eligibility

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Blood, Family History Information, and others for people with cancer. The study is currently recruiting participants at 7 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERFamily History Information

The family history ascertainment focuses on self-reported family history of first-, second-, and third-degree family members, including types of malignancies/ pre-malignant lesions and age at diagnosis.

GENETICORAGENE

Approximately 2-4mL of saliva may be collected in specialized Oragene DNA Self-Collection Kit tubes or buccal swab-based collection devices.

GENETICBlood

For select participants, 1-2 tubes of blood will be drawn for DNA and RNA analysis

OTHERSkin Biopsy

In certain circumstances, for Memorial Sloan Kettering participants and their family members, it may be necessary to obtain a skin biopsy.