RecruitingNCT03937453

A Pancreatic Cancer Screening Study in Individuals With New-Onset or Deteriorating Diabetes Mellitus

A PAncreatic Cancer Screening Study in Individuals With New-Onset or DeteriOrating Diabetes MEllitus (PANDOME Study)


Sponsor

Nuvance Health

Enrollment

800 participants

Start Date

Jan 19, 2018

Study Type

OBSERVATIONAL

Conditions

Summary

The main goal of this study is to explore the relationship between new-onset diabetes mellitus/deteriorating diabetes and a subsequent diagnosis of pancreatic cancer. Magnetic Resonance Imaging and Magnetic cholangiopancreatography (MRI/MRCP) will be utilized to screen for early stage pancreatic cancer or precursor lesions. Participants will be asked to donate a blood sample at specific intervals for the creation of a bio-bank necessary for the development of a blood based screening test for pancreatic cancer.


Eligibility

Min Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study is screening people with newly diagnosed or worsening diabetes for early signs of pancreatic cancer. Research has shown that new-onset diabetes in people over 50 can sometimes be an early sign of pancreatic cancer, and this study aims to detect it earlier when treatment is more effective. **You may be eligible if...** - You are at least 50 years old - You have been diagnosed with diabetes within the past 12 months - You have lab evidence of new or worsening blood sugar control (HbA1c of 6.5% or higher, or a fasting blood sugar result) - You had normal blood sugar levels documented within the past 2 years before the diabetes diagnosis **You may NOT be eligible if...** - You have a known history of pancreatic disease - You have already been diagnosed with pancreatic cancer - You have had prior pancreatic surgery - You have type 1 diabetes - Your diabetes is clearly explained by another cause (such as long-term steroid use) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTMRI/MRCP

An MRI/MRCP with IV gadolinium contrast with high resolution imaging of the pancreas will be performed at baseline. Further imaging upon recommendation by study committee


Locations(2)

Yale University

New Haven, Connecticut, United States

Nuvance Health

Norwalk, Connecticut, United States

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NCT03937453


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