RecruitingPhase 3NCT03952299

Oxybutynin for Post-surgical Bladder Pain and Urgency

Sponsor

University of California, Davis

Enrollment

100 participants

Start Date

Sep 1, 2021

Study Type

INTERVENTIONAL

Conditions

Overactive Bladder Syndrome Neuropathic Bladder

Summary

Bladder pain and urgency are common after bladder surgery. The objective is to determine if transdermal administration is superior to oral administration in alleviating pain and urgency.

Eligibility

Min Age: 4 YearsMax Age: 8 Years

Inclusion Criteria2

Patients who will undergo bladder surgery that requires an indwelling bladder catheter after surgery.
Age Range: Four to 8 years of age are eligible for the study.

Exclusion Criteria6

Patients who have had prior bladder surgery.
Patients who have neurologic disease that could impair bladder sensation.
Patients who are already taking antimuscarinic or antispasmodic medications.
Patients with glaucoma, any neurologic disease, dementia, impaired mentation or disorder of the central nervous system.
Patients taking any medication that affects the central nervous system such as antidepressant, anxiolytic or antipsychotic medications.
Less than four years of age cannot have the transdermal patch due to fixed dose. Over 8 years of age: less than 5% of our patients, who undergo this surgery, are over 8 years of age and is usually a rare adolescent. Data in an older cohort may confuse the results since they respond differently to bladder surgery due to larger incision and longer hospital stay with a catheter.

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