Tractography Guided Subcallosal Cingulate Deep Brain Stimulation for Treatment Resistant Depression

This study is testing deep brain stimulation (DBS) — a surgical procedure that places electrodes in a specific part of the brain — for people with severe, treatment-resistant depression that has not improved with multiple medications, therapy, or other treatments. The electrodes deliver small electrical pulses to regulate brain activity and improve mood. **You may be eligible if...** - You are between 21 and 70 years old - You have a confirmed diagnosis of major depressive disorder (MDD) that has lasted no more than 10 years - Your depression has not responded to at least 4 different types of antidepressant treatments - You first experienced depression as an adult (not in childhood) - You are not currently psychotic **You may NOT be eligible if...** - You have bipolar disorder or schizophrenia - You have active suicidal plans - You have had previous brain surgery - You have a pacemaker or other implanted device that could interfere with DBS - You are pregnant or planning to become pregnant Talk to your doctor to see if this trial is right for you.