RecruitingPhase 3NCT03955445

Long-term Efficacy, Safety and Tolerability of Iptacopan in C3G or IC-MPGN

An Open-label, Non-randomized Extension Study to Evaluate the Long-term Efficacy, Safety and Tolerability of Iptacopan (LNP023) in C3 Glomerulopathy or Idiopathic Immune-complex-membranoproliferative Glomerulonephritis


Sponsor

Novartis Pharmaceuticals

Enrollment

225 participants

Start Date

Oct 3, 2019

Study Type

INTERVENTIONAL

Conditions

Summary

This is an open-label extension study to evaluate the long-term efficacy, safety and tolerability of iptacopan in subjects with C3 glomerulopathy or idiopathic immune-complex-membranoproliferative glomerulonephritis


Eligibility

Min Age: 12 YearsMax Age: 100 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called LNP023 for people with c3 glomerulopathy and immune-complex-membranoproliferative glomerulonephritis. The study is currently recruiting participants at 50 locations. People eligible for this study include aged 12 Years to 100 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGLNP023

LNP023 capsules


Locations(50)

Childrens Hospital Colorado

Aurora, Colorado, United States

Georgia Nephrology Research Inst

Lawrenceville, Georgia, United States

University of Iowa Health Care

Iowa City, Iowa, United States

University of Minnesota

Minneapolis, Minnesota, United States

Col Uni Med Center New York Presby

New York, New York, United States

Novartis Investigative Site

CABA, Buenos Aires, Argentina

Novartis Investigative Site

Buenos Aires, Argentina

Novartis Investigative Site

Belo Horizonte, Minas Gerais, Brazil

Novartis Investigative Site

Recife, Pernambuco, Brazil

Novartis Investigative Site

Porto Alegre, Rio Grande do Sul, Brazil

Novartis Investigative Site

Botucatu, São Paulo, Brazil

Novartis Investigative Site

São Paulo, São Paulo, Brazil

Novartis Investigative Site

Salvador, Brazil

Novartis Investigative Site

Toronto, Ontario, Canada

Novartis Investigative Site

Beijing, China

Novartis Investigative Site

Shanghai, China

Novartis Investigative Site

Prague, Czechia

Novartis Investigative Site

Montpellier, France

Novartis Investigative Site

Paris, France

Novartis Investigative Site

Toulouse, France

Novartis Investigative Site

Erlangen, Germany

Novartis Investigative Site

Essen, Germany

Novartis Investigative Site

Hamburg, Germany

Novartis Investigative Site

Mainz, Germany

Novartis Investigative Site

Heraklion Crete., Greece

Novartis Investigative Site

Thessaloniki, Greece

Novartis Investigative Site

Petah Tikva, Israel

Novartis Investigative Site

Petah Tikva, Israel

Novartis Investigative Site

Ranica, BG, Italy

Novartis Investigative Site

Roma, Italy

Novartis Investigative Site

Nagoya, Aichi-ken, Japan

Novartis Investigative Site

Asahikawa, Hokkaido, Japan

Novartis Investigative Site

Sapporo, Hokkaido, Japan

Novartis Investigative Site

Takatsuki, Osaka, Japan

Novartis Investigative Site

Ohtsu, Shiga, Japan

Novartis Investigative Site

Hachiōji, Tokyo, Japan

Novartis Investigative Site

Niigata, Japan

Novartis Investigative Site

Leiden, South Holland, Netherlands

Novartis Investigative Site

Pamplona, Navarre, Spain

Novartis Investigative Site

Barcelona, Spain

Novartis Investigative Site

Madrid, Spain

Novartis Investigative Site

Madrid, Spain

Novartis Investigative Site

Seville, Spain

Novartis Investigative Site

Bern, Switzerland

Novartis Investigative Site

Köseköy, Kocaeli, Turkey (Türkiye)

Novartis Investigative Site

Kayseri, Melikgazi, Turkey (Türkiye)

Novartis Investigative Site

Ankara, Yenimahalle, Turkey (Türkiye)

Novartis Investigative Site

Newcastle upon Tyne, Tyne and Wear, United Kingdom

Novartis Investigative Site

Cardiff, United Kingdom

Novartis Investigative Site

London, United Kingdom

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NCT03955445


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