Trial to Assess Chelation Therapy in Critical Limb Ischemia

This trial tests whether chelation therapy — infusions of a chemical called EDTA that binds to and removes heavy metals from the body — can improve circulation and wound healing in diabetic patients with critical limb ischemia (CLI). CLI is a severe condition where blocked arteries in the leg cause rest pain, non-healing wounds, and risk of amputation. Some patients are not eligible for conventional revascularization surgery or have already had it fail, leaving few options. Participants receive a series of chelation infusions or placebo infusions over several months. The study tracks limb salvage rates, wound healing, pain, and quality of life. You may be eligible if: - You are 50 or older - You have diabetes and confirmed severe narrowing of leg arteries below the knee - You have critical limb ischemia (rest pain or non-healing wounds for at least 2 weeks) - You are not a candidate for, or have failed, revascularization surgery You may NOT be eligible if: - You have active infection, gangrene above the foot joints, or severe uncontrollable pain - You have significant kidney impairment (eGFR below 30) - You have smoked in the last 3 months - You are a woman of childbearing potential - You have active heart failure or were hospitalized for heart failure in the last 3 months Talk to your doctor to see if this trial is right for you.