The Efficacy of JS001 Combined With Chemotherapy in Patients With Locally Advanced Colon Cancer

This study combines the immunotherapy drug JS001 (an anti-PD-1 drug similar to pembrolizumab) with chemotherapy before surgery in patients with locally advanced colon cancer. The goal is to shrink the tumor enough to allow surgical removal. **You may be eligible if...** - You are 18 or older - You have locally advanced colon cancer confirmed by biopsy - Your cancer team has decided that pre-surgical (neoadjuvant) chemotherapy is appropriate - You have at least one measurable tumor on scans - Your ECOG score is 0-1 (able to perform normal daily activities) - Your blood counts and organ function are within acceptable ranges **You may NOT be eligible if...** - You have metastatic (widely spread) cancer - Your blood counts or organ function are outside acceptable limits - Your overall health level is too poor (ECOG 2 or above) Talk to your doctor to see if this trial is right for you.