Bariatric Surgery for Fertility-Sparing Treatment of Atypical Hyperplasia and Grade 1 Cancer of the Endometrium

This study is looking at whether bariatric (weight loss) surgery can improve the effectiveness of hormonal treatment (a progesterone-releasing IUD) for women with early-stage endometrial (uterine) cancer or a pre-cancerous condition called atypical hyperplasia, who want to preserve their fertility rather than have a hysterectomy. **You may be eligible if...** - Your BMI is 35 or higher - You have been diagnosed with grade 1 endometrioid endometrial cancer or complex atypical hyperplasia (a pre-cancerous uterine condition) - Your cancer is early-stage with no evidence of spread beyond the uterus on imaging - You want to preserve your ability to have children - You have no contraindications to a progesterone IUD **You may NOT be eligible if...** - Your cancer has invaded the uterine muscle wall or spread outside the uterus - You have a high-grade or aggressive type of endometrial cancer - You have had major upper abdominal surgery (such as previous bariatric surgery or liver resection) - You have another active cancer Talk to your doctor to see if this trial is right for you.