Study Compare Adjuvant Chemotherapy, Chemoradiotherapy and Surgery Alone for pN1-2(pT1b-3N1-2M0) Esophageal Carcinoma

This study is comparing three approaches after surgery for esophageal (food pipe) cancer that has spread to nearby lymph nodes: surgery alone, chemotherapy after surgery, or combined chemotherapy and radiation after surgery. The goal is to find the best way to reduce the chance of the cancer coming back. **You may be eligible if...** - You are between 18 and 75 years old - You had a complete (R0) surgical removal of thoracic esophageal squamous cell carcinoma - Your pathology confirmed lymph node involvement (pN1-2, stage pT1b-3N1-2M0) - You received no cancer treatment before surgery - Your heart, liver, and kidney function meet required thresholds - You are in good overall health (WHO performance status 0–1) **You may NOT be eligible if...** - Surgery used a left chest (left thoracic) approach - You had serious complications after surgery that prevent further treatment - You received prior systemic or radiation therapy for this cancer Talk to your doctor to see if this trial is right for you.