A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas

This study is testing a new experimental drug called EVOLVE104 for people with advanced cancers, specifically bladder cancer, squamous cell lung cancer, esophageal cancer, skin cancer, or cancers of the anal or genital area. Researchers are checking how safe and effective the drug is. **You may be eligible if...** - You have one of the following cancers that has spread or cannot be removed by surgery: bladder cancer, squamous cell lung cancer, esophageal cancer, skin squamous cell carcinoma, or anogenital squamous cell carcinoma - Your cancer has continued to grow or come back after standard treatments - Your cancer can be measured on a scan (CT or MRI) - You are generally functioning well day-to-day (ECOG score of 0 or 1) - Your life expectancy is at least 3 months **You may NOT be eligible if...** - There is a targeted drug known to work for your specific cancer type - You have ongoing, significant side effects from prior cancer treatment - You have untreated, unstable brain metastases - You have a history of severe immune reactions to cancer treatments - You have significant heart disease, severe esophageal problems, or serious eye inflammation Talk to your doctor to see if this trial is right for you.